Bioactive Small Molecules
Medchemexpress LLC Butabindide oxalate | 185213-03-0 | MFCD09971008 | 99.0% | 393.43 g/mol | C19H27N3O6 | 5 MG
Butabindide oxalate is a selective, potent inhibitor of tripeptidyl peptidase II (TPP II) used in biochemical and pharmacological research to inhibit TPP II activity and protect neuropeptides such as cholecystokinin-8 (CCK-8) from enzymatic degradation.
- Potent TPP II inhibition with Ki ≈ 7 nM.
- High selectivity over TPP I (Ki ≈ 10 μM).
- Supplied as an oxalate salt, white to off-white solid.
- High purity suitable for biochemical assays (≈99%).
- Available in small, laboratory-scale vials for research use.
eMolecules 871700-17-3 | Trametinib | Medchem Express | MFCD17215075 | 615.404 | C26H23FIN5O4 | 98.000 | CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O | 5mg | 808297295
Trametinib | Medchem Express | 871700-17-3 | MFCD17215075 | 615.404 | C26H23FIN5O4 | 98.000 | CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O | 5mg | 808297295
Cayman Chemical N-isopropyl-N-methyl Methylone (hydrochloride), Purity: ≥98%, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical ANTIBODY MPLA 100ug
A synthetic derivative of lipid A; a TLR4 agonist; increases injection site transcription of MyD88- and TRIF-dependent genes as well as genes encoding cytokines and cytokine receptors, chemokines, and molecules involved in the complement pathway and antigen presentation at 5 μg/100 μl, i.m.; increases the number of CD3+ T cells and CD11c+ GR1+ dendritic cells recruited to draining lymph nodes; increases serum levels of CCL2/MCP-1, CXCL1, CSF3, IL-6, and IL-10 by more than 10-fold compared to control animals; emulsions containing MPLA have demonstrated efficacy as vaccine adjuvants in several mouse models
Selleck Chemical LLC Adezmapimod hydrochloride E4791-1G
Adezmapimod hydrochloride (RWJ 64809 hydrochloride SB 203580 hydrochloride) is an inhibitor of the MAPK family member termed as stress-activated protein kinase 2a(SAPK2a also known as p38) It exhibits IC50 of SAPK2a/p38 and SAPK2b/p38 2 with IC50 values of 50 nM and 500 nM respectively and can be used in research of chronic inflammatory diseases such as rheumatoid arthritis
Cayman Chemical IMP-1088, Purity: ≥95%, CAS: 2059148-82-0, 5 mg
An inhibitor of N-myristoyltransferase (IC50 = 50 = >1,000 nM); blocks production of infectious RV-16 virus in primary hBECs
Cayman Chemical XMU-MP-1, Purity: ≥98%, CAS: 2061980-01-4, 10 mg
An inhibitor of MST1 and MST2 (IC50s = 71.1 and 38.1 nM, respectively); is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM; inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner; prevents cell death induced by overexpression of MST2; enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury when administered at a dose of 1 mg/kg
Medchemexpress LLC Pde9-in-1 | 2305087-92-5 | MFCD32062828 | 99.7% | 362.41 | C17H23FN6O2 | 10MG
PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) inhibitor with an IC50 of 8.7 nM. It demonstrates strong selectivity across PDE family enzymes and has shown in vivo efficacy: oral dosing at 2.5 and 5.0 mg/kg daily for 21 days improved learning and memory in a unilateral common carotid artery occlusion mouse model. Supplied as a solid, it is intended for biochemical and preclinical pharmacology studies.
- Molecular formula: C17H23FN6O2
- Molecular weight: 362.41 g/mol
- Purity: 99.7%
- Solubility: soluble in DMSO (100 mg/mL)
- Storage: powder -20°C (long term), in solvent -80°C (short term)
- Target: phosphodiesterase-9A (PDE9A); IC50 8.7 nM
- Form: solid
- Applications: biochemical assays and preclinical in vivo testing
eMolecules 1282514-88-8 | Medchem Express | GDC-0326 | 5mg | 446256634 | HY-101272 | MFCD30730064 | 382.424 | C19H22N6O3
Ambeed | 2-Ethoxy-1-fluoro-4-methylbenzene | 100mg | 717677659 | A1618232 | 1486959-73-2 | MFCD20219369 | 154.184 | C9H11FO
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Medchemexpress LLC GNE-7883 | 2648450-42-2 | 99.5% | 500.57 | 100 MG
GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. It effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and shows strong anti-tumor efficacy in vivo. Additionally, GNE-7883 overcomes intrinsic and acquired resistance to KRAS G12C inhibitors.
- Pan-TEAD inhibitor
- Blocks YAP/TAZ association with TEAD
- Reduces chromatin accessibility at TEAD motifs
- Inhibits cell proliferation
- Shows anti-tumor efficacy in vivo
- Overcomes KRAS G12C inhibitor resistance
- Targets YAP/TAZ-TEAD
- Soluble in DMSO (50 mg/mL)
Medchemexpress LLC MPEP (Hydrochloride) | 219911-35-0 | 99.82% | 229.70 | 25 MG
MPEP (Hydrochloride) is a potent, selective, noncompetitive, orally active, and systemically active mGlu5 receptor antagonist. It exhibits anxiolytic- or antidepressant-like effects and can be used as a click chemistry reagent.
- Potent, selective, noncompetitive mGlu5 receptor antagonist
- Exhibits anxiolytic- or antidepressant-like effects
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis
- Does not show agonist or antagonist activity on human mGlu2, -3, -4a, -7b, -8a, and mGlu6 receptors
Medchemexpress LLC Acth (1-14) Tfa (Adrenocorticotropic Hormone Fragment 1-14 Tfa) | 25696-21-3 | 96.1% | 1794.90 | 5 MG
ACTH (1-14) TFA is a fragment of adrenocorticotropin, a tropic hormone produced by the anterior pituitary, which plays a crucial role in regulating cortisol and androgen production. This research-grade peptide is involved in various cellular functions and is associated with conditions like Addison disease, Cushing syndrome, and Cushing disease.
- Regulates cortisol and androgen production
- Fragment of adrenocorticotropin
- Suitable for research applications
- High purity for reliable experimental results
- Available in various package sizes
Medchemexpress LLC Anticonvulsant agent 2 | 75220-84-7 | C21H17ClN2 | 1 ML
Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent that exhibits antiepileptic activity. It is for research use only and not sold to patients. In vivo studies showed that Anticonvulsant agent 2 decreased locomotor activity in rats with an inhibition rate of 21.01% and demonstrated antiepileptic activity with an inhibition rate of 24.45% in rats.
- Potent and orally active anticonvulsant agent
- Exhibits antiepileptic activity
- Decreases locomotor activity in rats
- Demonstrates antiepileptic activity in rats
- For research use only
Medchemexpress LLC D159687 | 1155877-97-6 | C21H19ClN2O2 | 50 MG
D159687 is a selective PDE4D inhibitor. It is for research use only and not sold to patients. This compound has a molecular weight of 366.84 and appears as a white to off-white solid with a purity of 98.42%.
- Selective PDE4D inhibitor
- Molecular weight of 366.84
- Solid appearance, white to off-white color
- High purity of 98.42%
- Soluble in DMSO at 150 mg/mL (408.90 mM)
- Induces a transient increase in CREB phosphorylation in HT-22 cell line
- Demonstrates potential for recruitment or enhancement of synaptic function in female Cynomolgus macaques
Medchemexpress LLC KTC1101 | 2764833-47-6 | 98.1% | 476.48 | 100 MG
KTC1101 is an orally active pan-PI3K inhibitor that inhibits the PI3K signaling pathway, reducing downstream AKT and mTOR phosphorylation, and decreases Ki67 expression. Its anti-tumor effect stems from a dual mechanism: directly inhibiting tumor cell growth and dynamically enhancing immune response.
- Induces G1 phase cell cycle arrest in various cell lines (0.1-50000 nM, 48 h).
- Shows anti-proliferative activity (IC50 20-130 nM) without significant apoptosis.
- Inhibits all PI3K isoforms (IC50s: PI3Kα 3.72 nM, PI3Kβ 36.29 nM, PI3Kδ 1.22 nM, PI3Kγ 17.09 nM).
- Reduces AKT and mTOR phosphorylation in WB experiments (0-125 nM, 48 h).
- Arrests tumor growth in mice xenografts (0-125 mg/kg/day for 14 days, p.o.) without recurrence.